Partner

University of Leiden, The Netherlands

Main Research Interest

The 14-3-3 proteins form a family of highly conserved proteins present in all eukaryotic tissues investigated. These proteins can bind more than 250 different intracellular proteins. In this way, the 14-3-3 proteins regulate the activity of enzymes, regulate the subcellular localization of proteins and stimulate protein-protein interactions. These activities are important for many cellular processes like apoptosis, the cell cycle, stress response and signal transduction. 14-3-3 proteins are related to a number of human diseases like cancer and neurological diseases as Parkinson’s disease, the Miller-Dieker syndrome and Alzheimer’s disease and are used in a diagnostic test for BSE (mad cow disease).

We use the yeast Saccharomyces cerevisiae as model organism to study fundamental aspects of 14-3-3 proteins. This organism has two genes encoding 14­3­3 proteins, BMH1 and BMH2. Disruption of each of these genes has little effect, whereas disruption of both genes together is lethal in most laboratory strains. As in higher eukaryotes, the S. cerevisiae 14-3-3 proteins are involved in many cellular processes and many different binding partners have been identified.

Role/Objectives in Translucent Project

Role of 14-3-3 proteins in cation homeostasis.

In several ways 14-3-3 proteins are related with cation homeostasis. In the context of the Translucent project we will develop a model describing the role of 14-3-3 proteins in cation homeostasis.

For more information see: http://biology.leidenuniv.nl/ibl/S2/research5.shtml

People


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