Partner

Autonomous University of Barcelona, Spain (coordination)

Main Research Interest

The UAB partner is composed by several members of the Yeast Molecular Biology Group (YMBG), headed by Joaquín Ariño, and of the Group of Biomedical Applications of NMR spectroscopy (GABRMN), headed by Carles Arús, in collaboration with key members (Teodor Parella, Miquel Cabañas) of the NMR facility at UAB (SeRMN). The YMBG is mainly interested in the cellular response to stress (saline, pH, oxidative, etc.), with special emphasis in the mechanisms involving protein phosphor-dephosphorylation events. In this context, the YMBG has characterized in the past the role of the Ppz1/Hal3 complex in salt tolerance and has developed a comprehensive study of the cellular responses to environmental alkalinization. The GABRMN has been involved in qualitative and quantitative analysis of the biochemical origin of the NMR spectral pattern of animal and cellular models of cancer as well as human/animal tumor biopsies and their extracts. Its current interests include the development of strategies for in vivo phenotyping of human brain tumors using magnetic resonance spectroscopy (MRS).

More information: YMBG and GABRMN

Role/Objectives in Translucent Project

The main goals of the UAB partner within Translucent are to understand how yeast cells remodel their gene expression program to face situation in which cation homeostasis is compromised, and how this affect the metabolic profile of the cell. We expect that this information will provide essential information about both short-time, as well as adaptive, long-term responses to changes, which will tell us about most of the cellular processes affected by alteration of cation homeostasis.

To this end, we propose:

  1. A genome-wide strategy to identify novel components of cation homeostatic mechanisms.

  2. A systematic approach, based in the intensive use of DNA microarrays, to define the transcriptional profiles associated to cells lacking specific genes involved in cation homeostasis (known or discovered in the previous objective) or/and subjected to alteration in the environmental cation composition.

  3. To obtain a broad picture, mainly based in NMR techniques, of the metabolic profile in cells that carry mutations in genes relevant for cation homeostasis or/and has been placed under cation stress situations.

People


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